![NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]](https://i.ytimg.com/vi/4uwJiJsvlBc/hqdefault.jpg "NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]")
NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]
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![NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]](https://library.sportingnews.com/styles/crop_style_16_9_mobile_2x/s3/2022-09/sporting-news-2022_three--way-split-33db2bb1-a7b7-41df-99df-19e1db31408f.png?itok=UeVLyQyw "NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]")
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![NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]](https://a.espncdn.com/photo/2019/0830/nfl_preview_16x9.jpg "NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]")
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![NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]](https://i.ytimg.com/vi/2QCDAIlKi6U/maxresdefault.jpg "NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]")
Picks for EVERY Week 1 NFL Game, Picks to Win, Best Bets, & MORE
![NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]](https://www.thelines.com/wp-content/uploads/2023/08/NFL-Week-1-odds-scaled-e1693345820551.jpg "NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]")
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![NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]](https://a3.espncdn.com/combiner/i?img=%2Fphoto%2F2023%2F0907%2Fr1221351_1296x729_16%2D9.jpg "NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]")
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![NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]](https://i.ytimg.com/vi/4QOgDKXxRMQ/hq720.jpg?sqp=-oaymwEhCK4FEIIDSFryq4qpAxMIARUAAAAAGAElAADIQj0AgKJD&rs=AOn4CLDi-8A6_6eqSNi_IQHXCgQVbBGklw "NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]")
NFL Week 1 Betting Guide: TOP UPSET PICKS [Rams vs Bills, Vikings vs Packers & More]
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